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Intensive Care Foundation’s Impact

23 September 2025

TARGET Protein Trial paper presented at 2025 Critical Care Reviews meeting in Belfast

We are proud to share the achievements of Dr Lee-anne Chapple, a Dietitian at Royal Adelaide Hospital, who was awarded an Intensive Care Foundation grant in 2021. Her important work has now been published in the world leading Journal of the American Medical Association (JAMA) and presented to the 2025 Critical Care Reviews meeting in Belfast to a large international audience.

Dr Chapple and her colleagues led the TARGET Protein Trial, a large-scale study involving eight intensive care units across Australia and New Zealand. The trial recruited more than 3,300 critically ill patients in just 12months, a remarkable achievement made possible with the support of the Foundation’s grant.

The study compared two enteral nutrition formulas, one with a higher protein content and one with the standard amount, to determine whether increased protein would help patients recover more quickly or survive longer. While the study did not show a benefit of higher protein dose in critical illness, the findings are meaningful for practice, providing clear evidence to guide safer protein delivery in critical care. 

Equally importantly, the trial has set the stage for future research. It has raised new questions about whether higher protein might help certain patient groups, or whether it may be best introduced later, during the recovery phase of critical illness. These insights are shaping the next generation of studies in ICU nutrition.

This achievement was only possible thanks to the generosity of the Intensive Care Foundation and its donors. Without this support, such a large and impactful trial could not have been completed.